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Automation systems for inhaler testing

Dissolution Testing


Tablet dissolution is a standardised means of measuring the in-vitro rate of drug release from a dosage form. The principle function of the dissolution test is:
  • To optimise therapeutic effectiveness during product development and stability assessment
  • Routine assessment of production quality to ensure uniformity between production batches
  • Assessment of ‘bioequivalence’, i.e. production of the same biological availability from discrete batches of products from one or different manufacturers
  • Prediction of ‘in-vivo’ availability, i.e. bioavailability
Tablets and capsules taken orally remain one of the most effective means of treatment. Effectiveness relies on the drug dissolving in the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial.

One of the problems facing the pharmaceutical industry is to optimise the amount of drug available to the body. Inadequacies in bioavailability can mean that the treatment is ineffective and at worst potentially dangerous (toxic overdose). Measuring drug release ‘in-vivo’is obviously impractical, official ‘in-vitro’ tests are therefore defined by the respective Pharmacopoeia.

Please see ´Related Solutions´ for details of RTS´ Dissolution Testing offer.