Automation systems for inhaler testing
Content uniformity testing is applicable to both solid dosage and inhaler testing applications and involves using a content/potency assay to determine the content of active material contained within multiple different samples collected throughout a batch.
Due to increased awareness of physiological availability, the content uniformity test has been included in the monographs of all coated and uncoated tablets and all capsules intended for oral administration. The test is used to ensure that every dose or tablet contains the claimed amount of drug substance with acceptable variation throughout the batch. Content Uniformity Testing is useful for assessing the consistency of:
- Powder blends before filling or compressing
- Semi-solid and liquid bulk batches before filling
- Filling during manufacturing (such as powders into capsules or inhalers, liquids into vials or bottles)
- Active content within individual units post-manufacturing (such as individual tablets after compression, consistency of inhaler dosage)